Thema: News: Fatale Blutung nach Radiochemotherapie

Surg Neurol 2002 Jan;57(1):46-8

Fatal hemorrhage after radiochemotherapy for leptomeningeal dissemination of glioma. report of two cases.

Saito R, Kumabe T, Jokura H, Yoshimoto T.

Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan

BACKGROUND:
Dissemination of malignant gliomas is often observed, but the treatment of choice for leptomeningeal dissemination has not been established.

CASE DESCRIPTIONSA:
55-year-old man suffered fatal hemorrhage 1 day after whole brain irradiation (2 Gy) along with intravenous administration of 150 mg of nitrosourea (ACNU) for leptomeningeal dissemination of glioblastoma.

A 14-year-old boy suffered hemorrhage after intrathecal administration of 10 mg of methotrexate for recurrence of leptomeningeal dissemination of anaplastic astrocytoma 4 months after local brain irradiation and ACNU administration, and died 19 days later.

CONCLUSION:
Massive fatal hemorrhage is an unusual but possible acute complication after radiochemotherapy for leptomeningeal dissemination of gliomas.

PMID: 11834277