Thema: News: Survivin in brain tumors
News: Survivin in brain tumors
Tom[a]
13.09.2003 21:40:34
Neurooncol. 2003 Aug-Sep;64(1-2):71-6
Survivin in brain tumors: an attractive target for immunotherapy.
Katoh M, Wilmotte R, Belkouch MC, de Tribolet N, Pizzolato G, Dietrich PY.
Laboratory of Tumor Immunology, Division of Oncology, University Hospital of Geneva, Geneva, Switzerland.
Survivin, a member of the inhibitor of apoptosis proteins gene family, was recently shown to be expressed by tumors originating from different cell lineages. There are also cumulative evidences that spontaneous immune response against survivin derived epitopes may occur. Here, using RT-PCR, Western-blot analysis and immunohistochemistry, we show that survivin is widely expressed by gliomas, meningiomas and schwannomas, both in vitro and in vivo. These data indicate that survivin may serve as an attractive target for immunotherapies designed for brain tumors.
Survivin in brain tumors: an attractive target for immunotherapy.
Katoh M, Wilmotte R, Belkouch MC, de Tribolet N, Pizzolato G, Dietrich PY.
Laboratory of Tumor Immunology, Division of Oncology, University Hospital of Geneva, Geneva, Switzerland.
Survivin, a member of the inhibitor of apoptosis proteins gene family, was recently shown to be expressed by tumors originating from different cell lineages. There are also cumulative evidences that spontaneous immune response against survivin derived epitopes may occur. Here, using RT-PCR, Western-blot analysis and immunohistochemistry, we show that survivin is widely expressed by gliomas, meningiomas and schwannomas, both in vitro and in vivo. These data indicate that survivin may serve as an attractive target for immunotherapies designed for brain tumors.
Tom[a]
