hallo.
ich hab ein paar informationen über seedsimplantationen gefunden, allerdings nur auf englisch:
BRACHYTHERAPY (brachy-Greek
for short), also called interstitial irradiation,
entails the surgical implantation of radioac-tive
sources directly into the brain permitting
a dose of radiation to be delivered locally
within the tumor while sparing the sur-rounding
brain tissue. In one technique, the
radioactive sources (in the form of seeds),
remain inside the tumor for usually six to
seven days before they are withdrawn. In
some cases, the sources are left in place per-manently.
The size of the tumor and its loca-tion
in the brain determine if seeds can be
implanted, how many seeds are implanted,
and how long they are left in place. Some-times,
when combined with surgery and con-ventional
radiation therapy, brachytherapy
has shown improved survival time for
patients with GBMs that meet specific criteria,
but those are still fairly few in number.
(Quelle: http://www.braintumor.org/pservices/pdfarchive/Brochure-Glio.pdf)
und:
A Phase II study of concomitant Gliadel Wafer and Iodine-125 seed implantation following surgical resection for Glioblastoma multiforme or Gliosarcoma.
The purpose of this study is to determine whether concomitant placement of I-125 low activity radioactive seeds and Gliadel wafers will safely and reproducibly produce responses, increase time to progression and increase length of survival.
This protocol will deliver radiation and chemotherapy directly into the tumor resection cavity. Patients will undergo repeat tumor resection with implantation of Gliadel chemotherapy wafers and I-125 permanent low activity radioactive seeds.
Glioblastoma multiforme and Gliosarcoma usually recur locally (at the resection margin) despite surgery and radiotherapy. In an effort to improve local control of these tumors, both Gliadel wafers, which deliver chemotherapy (Carmustine,BCNU) for approximately 8-12 weeks, and the I-125 seeds, which deliver radiation have been used with some success. Our goal is to determine whether using these two types of implants together will enhance the tumor response.
(Quelle:http://depts.washington.edu/neurosur/trials/tumors.html)
ich hoffe das hilft dir ein wenig weiter.
glückauf. jens.
