Thema: Weiß jemand wie es amanda1105 geht?
Weiß jemand wie es amanda1105 geht?
Pittiplatsch
16.12.2019 13:27:13
mannimagret
18.12.2019 20:38:07
magicmerle88
19.12.2019 11:52:00
LinaK
19.12.2019 14:18:38
Nach Fabi wollte ich auch schon fragen. Gruß Lina
LinaK
super_girl
19.12.2019 20:53:59
Thomas95267
23.12.2019 11:23:24
Fabi
28.01.2020 15:54:14
Huhu, ist ja lieb von euch. Mir geht’s echt super. Bin beruflich und familiär ordentlich eingespannt. Kurze Info:
Im MRT Juni 2019 wurde etwas „Neues“ festgestellt
MRT September 2019 weiterhin etwas „Neues“
Also PET- CT und große Aufregung... aber Entwarnung... völlig harmlos, kein neuer Tumor!
Ich bin weiterhin ein Freund von Curcuma und Co. glaube auch, dass es mir bis hier hin sehr gut geholfen hat. Und aktuelle Studien bestätigen ja auch den Nutzen!
In diesem Sinne denkt weiterhin alle positiv und genießt das Leben... ich werde jetzt mal wieder öfter vorbeischauen.
Lg Fabi
Im MRT Juni 2019 wurde etwas „Neues“ festgestellt
MRT September 2019 weiterhin etwas „Neues“
Also PET- CT und große Aufregung... aber Entwarnung... völlig harmlos, kein neuer Tumor!
Ich bin weiterhin ein Freund von Curcuma und Co. glaube auch, dass es mir bis hier hin sehr gut geholfen hat. Und aktuelle Studien bestätigen ja auch den Nutzen!
In diesem Sinne denkt weiterhin alle positiv und genießt das Leben... ich werde jetzt mal wieder öfter vorbeischauen.
Lg Fabi
Lissie38
28.01.2020 18:27:14
Fabi
28.01.2020 22:40:00
https://www.ncbi.nlm.nih.gov/m/pubmed/30864499/
Hmm liest sich hier anders... nur eines von vielen Beispielen
Therapeutic Potential of Curcumin in the Treatment of Glioblastoma Multiforme.
Shahcheraghi SH, et al. Curr Pharm Des. 2019.
Authors: Shahcheraghi SH1,2, Zangui M3, Lotfi M4, Ghayour-Mobarhan M5, Ghorbani A6, Jaliani HZ7, Sadeghnia HR8, Sahebkar A3,9,10.
Author information
1
Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
5
Metabolic Syndrome Research Center, Mashhad University of Medicine Sciences, Mashhad, Iran.
6
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
7
Protein Engineering Laboratory, Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
8
Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
9
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
10
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Citation
Curr Pharm Des. 2019;25(3):333-342. doi: 10.2174/1381612825666190313123704.
Abstract
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. Despite standard multimodality treatment, the highly aggressive nature of GBM makes it one of the deadliest human malignancies. The anti-cancer effects of dietary phytochemicals like curcumin provide new insights to cancer treatment. Evaluation of curcumin's efficacy against different malignancies including glioblastoma has been a motivational research topic and widely studied during the recent decade. In this review, we discuss the recent observations on the potential therapeutic effects of curcumin against glioblastoma. Curcumin can target multiple signaling pathways involved in developing aggressive and drug-resistant features of glioblastoma, including pathways associated with glioma stem cell activity. Notably, combination therapy with curcumin and chemotherapeutics like temozolomide, the GBM standard therapy, as well as radiotherapy has shown synergistic response, highlighting curcumin's chemo- and radio-sensitizing effect. There are also multiple reports for curcumin nanoformulations and targeted forms showing enhanced therapeutic efficacy and passage through blood-brain barrier, as compared with natural curcumin. Furthermore, in vivo studies have revealed significant anti-tumor effects, decreased tumor size and increased survival with no notable evidence of systemic toxicity in treated animals. Finally, a pharmacokinetic study in patients with GBM has shown a detectable intratumoral concentration, thereby suggesting a potential for curcumin to exert its therapeutic effects in the brain. Despite all the evidence in support of curcumin's potential therapeutic efficacy in GBM, clinical reports are still scarce. More studies are needed to determine the effects of combination therapies with curcumin and importantly to investigate the potential for alleviating chemotherapy- and radiotherapy-induced adverse effects.
Copyright© Bentham Science Publishers;
Hmm liest sich hier anders... nur eines von vielen Beispielen
Therapeutic Potential of Curcumin in the Treatment of Glioblastoma Multiforme.
Shahcheraghi SH, et al. Curr Pharm Des. 2019.
Authors: Shahcheraghi SH1,2, Zangui M3, Lotfi M4, Ghayour-Mobarhan M5, Ghorbani A6, Jaliani HZ7, Sadeghnia HR8, Sahebkar A3,9,10.
Author information
1
Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2
Infectious Diseases Research Center, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
3
Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
4
Department of Medical Genetics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
5
Metabolic Syndrome Research Center, Mashhad University of Medicine Sciences, Mashhad, Iran.
6
Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
7
Protein Engineering Laboratory, Department of Medical Genetics, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
8
Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
9
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
10
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Citation
Curr Pharm Des. 2019;25(3):333-342. doi: 10.2174/1381612825666190313123704.
Abstract
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. Despite standard multimodality treatment, the highly aggressive nature of GBM makes it one of the deadliest human malignancies. The anti-cancer effects of dietary phytochemicals like curcumin provide new insights to cancer treatment. Evaluation of curcumin's efficacy against different malignancies including glioblastoma has been a motivational research topic and widely studied during the recent decade. In this review, we discuss the recent observations on the potential therapeutic effects of curcumin against glioblastoma. Curcumin can target multiple signaling pathways involved in developing aggressive and drug-resistant features of glioblastoma, including pathways associated with glioma stem cell activity. Notably, combination therapy with curcumin and chemotherapeutics like temozolomide, the GBM standard therapy, as well as radiotherapy has shown synergistic response, highlighting curcumin's chemo- and radio-sensitizing effect. There are also multiple reports for curcumin nanoformulations and targeted forms showing enhanced therapeutic efficacy and passage through blood-brain barrier, as compared with natural curcumin. Furthermore, in vivo studies have revealed significant anti-tumor effects, decreased tumor size and increased survival with no notable evidence of systemic toxicity in treated animals. Finally, a pharmacokinetic study in patients with GBM has shown a detectable intratumoral concentration, thereby suggesting a potential for curcumin to exert its therapeutic effects in the brain. Despite all the evidence in support of curcumin's potential therapeutic efficacy in GBM, clinical reports are still scarce. More studies are needed to determine the effects of combination therapies with curcumin and importantly to investigate the potential for alleviating chemotherapy- and radiotherapy-induced adverse effects.
Copyright© Bentham Science Publishers;
der Meister
30.01.2020 09:20:40
LinaK
31.01.2020 17:19:06
Hey Fabi! Gut, wenn du mal piepst! Lina
LinaK